The web page provides the usual adult and pediatric doses, renal and liver dose adjustments, blood count monitoring, and precautions for hydroxyurea
A typical dosage of Hydrea may be 15 mg per kg of body weight taken once daily
Brand names: Hydrea and Droxia
3 DOSAGE FORMS AND STRENGTHS Capsules: 500 mg dark green opaque (cap) printed "724" in white ink/ pink opaque (body) printed "par" in black ink
In HIV patients with psoriasis, an initial dose of 500mg/d has been recommended, increasing to 1
Risk Summary
The effects of hydroxyurea are transient as the drug is rapidly cleared from the circulation
Hydroxyurea is usually taken once per day at the same time of day, with or without food
2 Here we compare the outcomes of "fixed low-dose" hydroxyurea in Nigeria with " azacytidine has unacceptable side effects
See more For oral dosage form (capsules): Adults—Dose is based on body weight and must be determined by your doctor
Dosage Take as directed Important considerations Drug Images Highlights for hydroxyurea Hydroxyurea oral capsule is available as brand-name drugs
usual
• Once stable dosing is achieved, monitor CBC with differential and reticulocyte count every 2–3 months
Initial suggested dose 500mg twice daily, maximum dose 2g/d
Despite evidence that hydroxyurea is effective for sickle cell anemia (SCA), implementation of the “maximum tolerated dose” regimen in adults is poor
The most tenable conclusion from the trial is that moderate-dose hydroxyurea is not superior (risk reduction not ≥80%) to low-dose hydroxyurea for
Importantly, computer program dosing recommendations were the same as manual dosing decisions made using the same algorithm for all 10 patients and at all times
The capsules are imprinted on both sections with “HYDREA” and “830” in black ink ( NDC 0003-0830-50)
75 and 1
Your doctor will tell you how to break the tablets and how many tablets or parts of a tablet you should take
15,38-41 When stated, all studies used a maximum dose of 30 to 35 mg/kg per day
Especially when the dose is escalated to the maximum tolerated dose, hydroxyurea improves laboratory variables and reduces clinical complications
The maximum daily dose of hydroxyurea should not exceed 35 mg/kg/d or 2000 mg/d; failure to achieve marrow suppression at these doses strongly suggests medication nonadherence
The dose is 15 milligrams (mg) per kilogram (kg) of body weight per day, taken as a single dose
It is recommended to start with a lower dose of 10–15 mg/kg/day and gradually increase in steps of 2
Hydroxyurea improves hematologic parameters for children with sickle cell disease (SCD), but its long-term efficacy at maximum tolerated dose (MTD) has not been determined
The hydroxyurea MTD is highly variable in SCA patients and ranges from 14
3, 4 Doses in this range may enhance survival, 6
• Once stable dosing is achieved, monitor CBC with differential and reticulocyte count every 2–3 months
PLT count normalized quickly and remained steadily below 300 × 10 9 /L after the dose of hydroxyurea was reduced to 500 mg per day