1125241 Genetic mechanisms involved in multidrug resistance of Candida albicans have recently been explored
In vitro susceptibility testing showed a minimum inhibitory concentration (MIC) to fluconazole of 1 microg/mL
dubliniensis, C
MIC, mcg/mL: Range: 50 percent* 90 percent* Candida albicans: Amphotericin B ¶ 2728: 0
25: 1: Fluconazole: 5827: 0
tropicalis isolates from immunocompromised (29) and immunocompetent (21) patients by minimum
21, 22 The emerging yeast C
A study by Clancy et al tested 32 Candida isolates from blood cultures of patients with candidemia for in vitro susceptibility to fluconazole and determined if the
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Candida tropicalis is an important cause of invasive candidiasis with a 30-day mortality as high as 40–50% [1,2]
MBIC was done using the calorimetric indicator resazurin, to measure the metabolically All Candida auris isolates should undergo antifungal susceptibility testing according to CLSI guidelines
Therefore, breakpoints are defined based Candida parapsilosis is one of the most commen causes of life-threatening candidaemia, particularly in premature neonates, individuals with cancer of the haematopoietic system, and recipients of organ transplants
2–9% of all cases of IC: Worldwide: Neutropenia, pediatric patients on broad spectrum antibiotics: Switching susceptibility to amphotericin B: Routine diagnostics cannot different it from C
Candida glabrata from blood culture
According to the NCCLS M27-A standard, infection was considered to be antifungal resistant if cultured Candida spp
It has been used for treating Candida infections, and is effective in treating infections caused by strains of Candida albicans, Candida tropicalis and Candida parapsilosis without acquired resistance mechanisms
Treatment was started with 400 mg of fluconazole administered intravenously every 12 h
glabrata, C
Genetic mechanisms involved in multidrug resistance of Candida albicans have recently been explored
5%
krusei can cause superficial infections of the oral and vaginal mucosa as well as disseminated bloodstream and deep-tissue infections
Candida albicans is the most common reported species, followed by C
The MIC distributions are Candida tropicalis 0 0 2 119 443 743 513 269 60 24 27 10 9 10 0 0 2 ECOFF, epidemiological cut-off value (mg⁄L) as defined by EUCAST
Additionally, these two combinations showed similar synergistic interactions against other medically important Candida species such as C
9% of all tested Candida albicans strains causing candidemia (n = 203)
Clinical breakpoints (CBPs) and Epidemiological Cut-Off (ECV) values based on MICs or MECs for Candida and Aspergillus species as endorsed by CLSI
1, 2 As fluconazole shows fungistatic activity against Candida, the minimum inhibitory concentration (MIC) has been defined as the lowest concentration yielding a 50% reduction in growth compared with a control
CLSI: Clinical and Laboratory Standards Institute; MIC: minimum inhibitory concentration