Nifedipine is generally well tolerated and side effects are largely due to its vasodilating activities and can include dizziness, flushing, headache, fatigue, nausea, diarrhea, palpitations, bradycardia, peripheral edema and skin rash
It has very similar kinetic, but it produces greater venodilation compared to arteriolar dilation
Descriptions Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension)
Nifedipine is in a class of medications called calcium
Side effects Interactions Dosage Take as directed Cost Important considerations Alternatives Important warnings Other warnings Highlights for nifedipine
Vasodilatory edema, a common adverse effect of antihypertensive therapy with vasodilators, is related to several mechanisms, including arteriolar dilatation (causing an increase in
Background —Dihydropyridine calcium channel blockers protect endothelial cells against ischemia and reperfusion injury, suggesting that nifedipine may
These results suggest that, at a dose of 10 mg, nifedipine does not venodilate and the veno- dilatory effect of nitroglycerin is not altered by pre- treatment with
Professor Hashimoto demonstrated that
For example, a vasodilator may cause water retention, which can raise pressure and lead to congestive heart failure
Chronic stable angina - Nifedipine reduced the frequency of angina and increased the mean exercise time in the IMAGE trial
unusual weakness or tiredness
The available calcium channel blocking agents block receptors on the L-type calcium channel which gives rise to a slowly inactivating high threshold
It consists, however, of a semipermeable membrane surrounding an osmotically active drug core
Aortic-valve replacement was indicated in 7 patients owing to the presence of symptoms (2 in the control group, 2 in the enalapril group, and 3 in the nifedipine group), in 15 patients because of nifedipine found similar rates of healing and pain relief
first dihydropyridine available and serves as the prototype for the group
Circulation
Nifedipine is widely used as a tocolytic, since it is well tolerated and inexpensive, nonetheless it should be considered that it can cause severe hypotension
7 mg/kg per day) for 2 weeks
Results: Core temperature decreased 0
At an equal antihypertensive efficacy, lercanidipine and lacidipine are associated with less vasodilatory edema than amlodipine and nifedipine
It has a molecular weight of 346