5 times the half life
An increase in C max and AUC of IR and ER formulations of metoprolol were reported with co-administration of paroxetine at a dose of 20 mg/day and half-life (t ½) of metoprolol for CYP2D6*10/*10 Key takeaways: Metoprolol tartrate (Lopressor) and metoprolol succinate ER (Toprol XL) are two forms of metoprolol-based medications
Approximately 95% of the dose can be recovered in urine
5–25 mg once daily (of extended-release), can be doubled every 2 wk up to 200 mg/day
4 hours
When administered orally, it exhibits stereoselective metabolism that is dependent on oxidation phenotype
The systemic availability and half-life of metoprolol in patients with renal failure do not differ to a clinically significant degree from those in normal subjects
This is because the med is designed in such a way that it supports tablet splitting and it does not damage the modified-release properties
The half life of Metoprolol Tartrate is only 3-7 hours
The mean elimination half-life of metoprolol is 3 to 4 hours; in poor CYP2D6 metabolizers the half-life may be 7 to 9 hours
In most subjects (extensive metabolizers), less than 5% of an oral dose and less than 10% of an intravenous dose are excreted as unchanged drug in the urine
rapid weight gain
3,4 Bisoprolol, metoprolol succinate and nebivolol can be Metoprolol succinate (Toprol XL) is used to treat hypertension and to control chronic (long-term) chest pain
In most subjects (extensive metabolizers), less than 5% of an oral dose and less than 10% of an intravenous dose are excreted as unchanged drug in the urine