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Bupropion overdose has also been implicated in serotonin toxicity
Serotonin toxicity (commonly referred to as serotonin syndrome) is a potentially life-threatening drug-induced condition caused by too much serotonin in the synapses of
October 1, 2021 by Josh Farkas
In the UK up to October 2020, the Yellow Card scheme has received 3 reports of serotonin syndrome associated with bupropion, one of which was a potential
A long half-life of drugs can lengthen a course of serotonin syndrome
Studies confirm that bupropion is still effective for treating mood disorders
2020
Along with its needed effects, a medicine may cause some unwanted effects
Bupropion is an aminoketone antidepressant with a mechanism that is not fully understood
Most antidepressants act through increasing the synaptic levels of serotonin or noradrenaline (norepinephrine) through various pharmacological mechanisms
Bupropion may cause some people to be agitated, irritable, or display other abnormal behaviors
Side Effects
After 3 days of dosing, the dose may be increased to 300 mg/day, given as 100 mg 3 times daily, with at least 6 hours between successive doses
It is also used as part of a support program to help people stop smoking
(Selective Serotonin Reuptake Inhibitors [SSRIs] and others) show that these drugs increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents
Serotonin syndrome symptoms include agitation, blood pressure change, fever, rapid heart rate, seizures and twitching muscles
Mechanism of action as an adjunct in the
Serotonin syndrome most often occurs when two medications that raise the level of serotonin are combined
See also Warning section
sleep problems, such as insomnia or sleepiness (making you tired) increased or decreased libido (sex drive) sweating, which may include night Serotonin syndrome is a serious drug reaction
Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies
Conclusion: The incidence of bupropion induced serotonin toxicity is higher than reported
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